|
Symbol Name ID |
Scn5a
sodium channel, voltage-gated, type V, alpha MGI:98251 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Left atrial enlargement |
Left ventricular hypertrophy |
Right ventricular dilatation |
Mitral valve prolapse |
Left ventricular noncompaction |
Dilated cardiomyopathy |
Stroke |
Reduced left ventricular ejection fraction |
Elevated left ventricular end-diastolic diameter |
Aortic regurgitation |
Aortic valve stenosis |
Tricuspid regurgitation |
Hypertension |
Absent P wave |
Prolonged P wave |
Prolonged PR interval |
Prolonged QRS complex |
Prolonged QT interval |
Prolonged QTc interval |
ST segment elevation |
Sick sinus syndrome |
Sinus bradycardia |
Bradycardia |
Cardiac arrest |
Sudden cardiac death |
Palpitations |
Atrial fibrillation |
Paroxysmal atrial fibrillation |
Permanent atrial fibrillation |
Atrial flutter |
Atrial standstill |
Premature atrial contractions |
Supraventricular tachycardia |
Supraventricular tachycardia with an accessory connection mediated pathway |
Ventricular tachycardia |
Ventricular flutter |
Premature ventricular contraction |
Torsade de pointes |
Ventricular escape rhythm |
Ventricular fibrillation |
Atrioventricular block |
Complete heart block with broad QRS complexes |
Left bundle branch block |
Left anterior fascicular block |
Left posterior fascicular block |
Right bundle branch block |
Myocardial infarction |
Reduced systolic function |
Syncope |
| Disease(s) Associated with SCN5A | |||||||||||||||||||||||||||||||||||||||||||||||||
| Brugada syndrome 1 | |||||||||||||||||||||||||||||||||||||||||||||||||
| dilated cardiomyopathy 1E | |||||||||||||||||||||||||||||||||||||||||||||||||
| familial atrial fibrillation | |||||||||||||||||||||||||||||||||||||||||||||||||
| long QT syndrome 3 | |||||||||||||||||||||||||||||||||||||||||||||||||
| progressive familial heart block type IA | |||||||||||||||||||||||||||||||||||||||||||||||||
| sick sinus syndrome |
| Mouse Phenotypes | cardiovascular system phenotype |
liver vascular congestion |
decreased myocardial fiber number |
increased myocardial fiber size |
abnormal trabecula carnea morphology |
abnormal heart morphology |
abnormal heart atrium morphology |
increased heart weight |
abnormal heart ventricle morphology |
thick ventricular wall |
cardiac fibrosis |
abnormal cardiovascular system physiology |
abnormal cardiac muscle contractility |
abnormal heart echocardiography feature |
abnormal heart rate |
decreased heart rate |
sinus bradycardia |
ventricular tachycardia |
irregular heartbeat |
ventricular fibrillation |
ventricular premature beat |
abnormal impulse conducting system conduction |
abnormal atrioventricular bundle conduction |
abnormal atrioventricular node conduction |
prolonged PR interval |
atrioventricular block |
abnormal heart electrocardiography waveform feature |
prolonged P wave |
prolonged PQ interval |
prolonged QRS complex duration |
abnormal QT interval |
prolonged QT interval |
abnormal T wave |
abnormal sinoatrial node conduction |
abnormal myocardial fiber physiology |
abnormal myocardial fiber sodium currents |
congestive heart failure |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||
| Scn5aem1Coop/Scn5aem1Coop | ||||||||||||||||||||||||||||||||||||||
| Scn5atm1Agrc/Scn5atm1Agrc | ||||||||||||||||||||||||||||||||||||||
| Scn5atm1Clhh/Scn5atm1Clhh | ||||||||||||||||||||||||||||||||||||||
| Scn5atm1Pec/Scn5atm1Pec | ||||||||||||||||||||||||||||||||||||||
| Scn5atm2.1Care/Scn5atm2.1Care | * | |||||||||||||||||||||||||||||||||||||
| Scn5aem1Coop/Scn5a+ | ||||||||||||||||||||||||||||||||||||||
| Scn5atm1.1Iba/Scn5a+ | ||||||||||||||||||||||||||||||||||||||
| Scn5atm1Agrc/Scn5a+ | ||||||||||||||||||||||||||||||||||||||
| Scn5atm1Care/Scn5a+ | ||||||||||||||||||||||||||||||||||||||
| Scn5atm1Clhh/Scn5a+ | ||||||||||||||||||||||||||||||||||||||
| Scn5atm1Pec/Scn5a+ | ||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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